Neauvia organic – The new 2nd generation of organic HA fillers


Hyaluronic acid (HA) fillers owe their popularity to good results, low intrusiveness and safe application. However, there are rare cases where a patient’s body reacts to them against expectations.

Why does this happen?
Currently, the most popular source of HA are laboratory strains of Streptococcus.
In fact, extracting the precious acid out of them requires the bacteria membrane breaking and application of chemical solvents. Contaminants present in the nished product are precisely the residues of bacteria and solvents. Despite several purifying processes, today’s technology is unable to fully eliminate these impurities.



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The purest form of hyaluronic acid currently available is obtained from Bacillus subtilis. This bacterium, which is non-pathogenic to humans, produces HA in a process based on water usage.

Unquestionable advantages of Bacillus Subtilis Hyaluronic Acid:

  • Ultra purity
  • High safety of application
  • Pre-determined molecular mass
  • Possibility to apply high HA concentration
  • Long shelf life


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Safety and effectiveness of llers also depend on how they are stabilized. Usually BDDE (a crosslinking agent) is used for this purpose. Due to its toxicity, it is assumed that the lower its content is, the safer is the product. However, low amount of cross-linker reduces longevity and performance in the tissue.

No more choosing between safety and permanent effect

While others wonder how to reduce the content of undesired substances, the scientists working on Neauvia Organic llers decided to apply a new crosslinker PEG polymer (not a common monomer like DVS or BDDE used in all the other products on the market). PEG is a well-known polymer on the pharmaceutical market, but it has been used for the first time in ller production by Neauvia.

PEG outstanding advantages:

  • Not-toxicandcompletelydegradableinthetissues
  • Reduces the action of proteolytic enzymes, like hyaluronidase, increasing the longevity of the implant
  • Stops the immunological reaction, as the implants is not recognized as a foreign body

PEG makes Neauvia Organic the most biocompatible fillers on the market reducing almost to zero the biopotential rejection of the hosting tissues.


Protective action of PEG is able to mask the implant from the host organism reducing the risk of immunological reaction and formation of the foreign body giant cells (FBGC). In other words, PEG reduces in ammation and granulomas formation. Moreover, it delays the degradation and the bioabsorbtion of the implant. PEG makes Neauvia llers the rst, one and only BIOMIMETIC llers worldwide.



IPN stands for Interpenetrating Polymer Network, which is an innovative and advanced technology to combine two different polymers – here HA and PEG – in one network that gives outstanding mechanical, rheological and thermosensitive properties to Neauvia llers. The use of this technology in Neauvia Organic llers is possible thanks to PEG, which, unlike other current cross-linker agents, is a polymer.
These kinds of IPN structures can be degraded only with the break of the chemical bonds, which means that the ller is much more resistant to mechanical stress that is the rst natural cause of the degradation of the implant.
The aim of IPN is to improve the weak properties of the single polymers; the combination of 2 polymers with IPN technique is improving both polymers performances. For instance, hyaluronic acid is a tremendously important component of our tissues, but really sensitive to heat! At certain temperatures, like the ones reached with aesthetic medicine treatments like lasers, ultrasounds or RF, any HA ller on the market is spoiled, besides Neauvia ones! PEG makes the HA much more resistant to heat, not limiting the range of aesthetic procedure available in beauty clinics and hospitals.[ux_custom_products products=”12″ columns=”3″ cat=”neauvia”]